Jul 162013
 July 16, 2013

marijuana science research cannabis alzheimersBy TheJointBlog.Com

new study conducted by researchers at the Roskamp Institute in Florida, and published in the journal Molecular and Cellular Neuroscience, has found that cannabis can slow the effects of Alzheimer’s Disease, and may in fact be able to halt it entirely.

According to Corbin Bachmeier, Ph.D – who’s the lead researcher of the study – Alzheimer’s Disease is “the result of impaired Aβ [Amyloid-β protein] clearance from the brain”. According to this study, cannabis can solve this problem, making it a potential treatment.

Here’s the study’s abstract:

Emerging evidence suggests beta-amyloid (Aβ) deposition in the Alzheimer’s disease (AD) brain is the result of impaired clearance, due in part to diminished Aβ transport across the blood-brain barrier (BBB). Recently, modulation of the cannabinoid system was shown to reduce Aβ brain levels and improve cognitive behavior in AD animal models. The purpose of the current studies was to investigate the role of the cannabinoid system in the clearance of Aβ across the BBB. Using in vitro and in vivomodels of BBB clearance, Aβ transit across the BBB was examined in the presence of cannabinoid receptor agonists and inhibitors. In addition, expression levels of the Aβ transport protein, lipoprotein receptor-related protein1 (LRP1), were determined in the brain and plasma of mice following cannabinoid treatment. Cannabinoid receptor agonism or inhibition of endocannabinoid-degrading enzymes significantly enhanced Aβ clearance across the BBB (2-fold). Moreover, cannabinoid receptor inhibition negated the stimulatory influence of cannabinoid treatment on Aβ BBB clearance. Additionally, LRP1 levels in the brain and plasma were elevated following cannabinoid treatment (1.5-fold), providing rationale for the observed increase in Aβ transit from the brain to the periphery. The current studies demonstrate, for the first time, a role for the cannabinoid system in the transit of Aβ across the BBB. These findings provide insight into the mechanism by which cannabinoid treatment reduces Aβ burden in the AD brain and offer additional evidence on the utility of this pathway as a treatment for AD.

This research validates past studies (including some presented earlier this year, as well as a 2006 study), though is the first to actually explain why cannabis can be beneficial to the disease.

Source: The Joint Blog

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About Johnny Green

Johnny Green is a marijuana activist from Oregon. He has a Bachelor's Degree in Public Policy. Follow Johnny Green on Facebook and Twitter. Also, feel free to email any concerns.
  • df

    What else does the US government need to reschedule this substance?…. what else? … Isn’t one of the main criteria of schedule 1 being that the substance has to have no medicinal value? Of course they completely ignore that. I mean cocaine is schedule 2.. wtf

    It’s only been proven to strongly help seizures, alzheimers, cancer, chronic pain issues, and diabetes… (and a lot more) ..

    • Matao

      The government knows all these studies. Cocaine apparently has more benefits than marijuana. BULLSHIT. They can move oxycotton but not cannabis

    • df

      Interestingly after i posted this it looks like ASA is right on their case to appeal their last scheduling ruling, which just defied all logic. (Despite all the scientific evidence, public support, a valid petition, etc etc etc)

    • Rose Rose

      I have epilepsy, and let me tell you, for me, no other med comes close to high CBD marijuana when it comes to treating seizures!

  • firetheliberals

    I would rather get stoopid on weed than become a vegetable with alzheimers..

    • Robert Dewayne King

      Fine , As long as we can tell the differance !! :)

  • Mike

    What an irony. Nancy Reagan and her buffoonish husband are both gone now, with the former president’s brain going to rot on Alzheimer’s. I wonder if she’d still “Just say no” if marijuana turns out to be an effective treatment for that tragic disease?

  • Mr. Bogart

    We all know why marijuana is a schedule I drug, it is the foundation of the DEA that was formed in the Nixon era, regardless of the studies done back in the ’60s.

    We all know, including the federal government, the benefits from marijuana and the list just keeps getting bigger and bigger every year.

    We all need to stop electing the idiots that get into office and marijuana should be, at the very least a schedule III drug.

    Also this is the biggest push trying to legalize marijuana since I was a kid back in the ’60s. Slowly inching along to finally having marijuana being made legal again and for the right reasons.

    I have seen 1st hand the devastation of what heroine, cocaine and meth has done to people and for me those drugs should never be legalized and I know that there are some that would differ and that’s OK.

  • Andrew Zebrun III

    NO NO nancy Reagan smokes “medical marijuana”! D.A.R.E. TERRORIST TRAITOR! Legalize cannabis for all! http://www.newsophile.com/2008/10/nancy-reagan-smokes-bad-weed-falls-and.html