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Pharmaceutical Company Starts First Human Trials For Cannabis Treatment For Brain Cancer

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gw pharmaceutical brain cancer cbd thc cannabisThe pharmaceutical industry taking over the marijuana industry has been something marijuana reform supporters have worried about for a long, long time. I personally don’t want to see a marijuana monopoly by the pharmaceutical industry, and I’m sure you don’t either. On the flip side of that, I do support sick patients getting the medicine they need to alleviate/cure their conditions. It looks like GW Pharmaceuticals is starting human trials to research how THC and CBD interacts with brain cancer cells. How do you feel about this? Below is a press release from the company explaining more:

GW Pharmaceuticals plc (Nasdaq: GWPH, AIM: GWP, “GW”) a biopharmaceutical company focused on discovering, developing and commercializing novel therapeutics from its proprietary cannabinoid product platform, announced today it has commenced a Phase 1b/2a clinical trial for the treatment of Recurrent Glioblastoma Multiforme (GBM).

Glioma describes any tumor that arises from the glial tissue of the brain. GBM is a particularly aggressive tumor that forms from abnormal growth of glial tissue. According to the New England Journal of Medicine, GBM accounts for approximately 50% of the 22,500 new cases of brain cancer diagnosed in the United States each year. Treatment options are limited and expected survival is a little over one year. GBM is considered a rare, or orphan, disease by the FDA and the European Medicines Agency, or EMA.

This study follows several years of pre-clinical research conducted by GW in the field of glioma which has demonstrated that cannabinoids inhibit the viability of glioma cells both in vitro and in vivoi,ii via apoptosis or programmed cell death, may also affect angiogenesis, and have demonstrated tumor growth-inhibiting action and an improvement in the therapeutic efficacy of temozolomide, a standard treatment for glioma. In addition, GW has shown tumor response to be positively associated with tissue levels of cannabinoids. GW has identified the putative mechanism of action for our cannabinoid product candidate, where autophagy and programmed cell death are stimulated via stimulation of the TRB3 pathway.
“We are very excited about moving this compound into further human study and the prospects of cannabinoids as new anti-cancer treatments. This is GW’s first clinical study of cannabinoids as a potential treatment to inhibit tumor growth,” stated Dr. Stephen Wright, Director of Research and Development at GW. “We believe this clinical program demonstrates the flexibility and broad application of GW’s cannabinoid platform to treat significant, unmet therapeutic needs.”

This study is a 20-patient, multicentre, two part study with an open-label phase to assess safety and tolerability of GW cannabinoids in combination with temozolomide, and a double blind, randomised, placebo-controlled phase with patients randomised to active or placebo, and with a primary outcome measure of 6 month progression free survival. The study objective is to assess the tolerability, safety and pharmacodynamics of a mixture of two principal cannabinoids, THC and CBD in a 1:1 allocation ratio, in combination with temozolomide in patients with recurrent GBM. Secondary endpoints include additional pharmacokinetic and biomarker analyses and additional measurable outcomes of tumor response.

Source: PRNewswire

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100 Comments

  1. I have been reading about the clinical trial for this new GW pharm product which brought me to this forum which I hope can help me. My daughter is 15 years old she has a brain tumor, grade II giloma. She has been on and off chemo since she was diagnosed with it at 4 years old, just a baby. She had surgery when she was 4 to remove the tumor, the surgeons destroyed her cerebellum in the process. She, a healthy 4 year old child, except for the tumor, was brought into the hospital one day running, playing, laughing, singing then two days later came out of surgery a vegetable. She is disabled from that surgery and will never lead the life she would have, but we have moved on from that. She has made improvements with a lot of physical therapy and hard work. At 15 she is a miracle, she goes to school, walks using a walker and has regained the ability to speak. She has had multiple recurrences of this tumor and has been on 5 different chemo protocols over the past 11 years. She is finishing the current protocol this month. She still has multiple tumors in her brain and one of them in her temporal lobe that causes her to have daily seizures. I have tried RSO for her but she is small for her age only 90lbs and it knocks her out to the point that she cannot function and it seemed to make the seizures worse. I have her on CBD oil from Dixie Botanicals because I can get that legally through the mail, however is has such a low concentration of CBD I don’t think it is really doing much. If a pharmaceutical company comes out with a CBD product that can help my child then I am all for it. We live in a state where you cannot legally purchase it so I am stuck. I do not trust pharm companies. I have lived this nightmare for 11 years now watching my daughter suffer. Most of the chemos she has been on cause more side effects than they are worth. Some of them slow the rate of growth of the tumor but at the risk of causing secondary cancers all while causing pain and suffering to the child. My fear is that this pharm company will modify the meds so that it doesn’t “cure” anything but just keeps the cancer in check so you have to take it for the rest of your life. Their goal is not to cure but to “treat” because cures result in people not needing the meds anymore but treatment results in long term customers. Beyond that I am desperate to help my daughter. The seizures are awful. She already has a hard time trying to live a normal life but with now having seizures on top of everything else it is horrible for her. If anyone on this forum has any suggestions on how I can get the type of oil with high CBD and low THC for my daughter I would be forever grateful. For now I have no choice but to pray that this pharma company gets their product approved for use and fast!

  2. We don’t have adverts for drugs in England,I’m sure they have them somewhere but not on the T.V. or in the papers..Only in the U.S.lol.

  3. Serg Azramenco on

    It looks like you don’t know shit. I a lot of countries it is not illegal to grow the plants and cure yourself.

  4. as soon as I hear “aspergillus” I know it’s a disinfo troll; go away JohnBoy Prohibitch! I was temrinally-ill not very long ago and thanks God for cannabis I’m still here demanding my right to His natural cures. “pHarmaceutical grade” is chemo with 70%+ failure rate, not to mention compromising immune system opening patients up to ALL sorts of creepy ailments. God made the plant, there’s nothing wrong with it, it’s never killed ANYONE and I could get aspergillus on my frickin Publix-bought broccoli; that straw-man is fluff!

  5. And let the games begin! :/ They have known since 1974 the Cannabis kills cancer and treats successfully, many chronic illnesses ! with out side effects!!!!!They have knowingly kept it from the public so they could continue to profit on the illnesses of people that by the way they have a lot to do with!!! :( they are killing us with all the toxic poison they are putting in our food water air and on our crops :( Monsanto for one they are allowed to spray round up on our plants that is really asin orange the chemical war gas they used in the Golf war :( and we are not stopping them, Why!!!!! As for the FDA protecting people that is not what they do and that group of people were not put there to do that :/ They were put in place to protect Pharmaceuticals stocks and to help them profit i would put all the facts but it is easy enough to research it…. So Please do we the people have been deceived for a good long time now and we are paying for it :(

  6. I still fail to extract any kind of point or reasoning from your gibberish. You don’t seem to suffer from much except brainwashing.

  7. Judging by the legalization, regulation and taxation laws and ‘gotchas’ they are writing into the laws, (Notice none of this crap is anywhere to be found in the alcohol tax models) they still intend to hang on a tight as they can, before it gets away from them. The mandatory blood levels in the nanogram range and the new breathalyzer they want to use, is further proof that they, ‘the powers that be’, will harass and intimidate us until they can get a few patents out of it (our Government has registered one already). In Washington state, the King county Sheriff’s Office, and a local television station has already done testing and visual study of the effects of cannabis on drivers. Light user, occasional user, and a heavy user with a medical marijuana card from the state. They had a certified state driving instructor, a couple of the Sheriff’s Deputies, a medical response team standing by, and the film crew. It is interesting to see and learn from what they found, but it has been thrown out with the bathwater, when it comes to the Power that be, not wanting to learn anything. I mean, Denver had to hold a vote about whether it was against the law to smoke in your own yard, on your damn porch!!! Yes, it is lawful to smoke it on your own property, but I’d be real careful about who can see you, as there are still malicious people out there, who will call the cops on you, if they see their kids in any proximity to you. Not like you will be giving them any! They can buy their own!

  8. And another patent is born:
    London, UK, 11 December 2013: GW Pharmaceuticals announced that the United States Patent and Trademark Office has issued a Notice of Allowance for U.S. Application Serial Number 12/996,124, a patent which covers the use of cannabinoids for treating glioma.

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