May 112012
 May 11, 2012

Medical LeafStudy: Administration Of Non-Psychotropic Cannabinoid Mitigates Psychotic Symptoms In Schizophrenics

The administration of the non-psychotropic plant constituent cannabidiol (CBD) is associated with a significant reduction in psychotic symptoms in patients with schizophrenia, according to clinical trial data published in the journal Translational Psychiatry.

An international team of researchers from Germany and the United States performed a four week, double-blind, randomized clinical trial assessing the clinical relevance of cannabidiol versus amisulpride, a potent antipsychotic agent, in patients with acute schizophrenia.

Researchers reported that the administration of either substance was associated with significant clinical improvement, but they acknowledged, “[C]annabidiol displayed a markedly superior side-effect profile.”

Amisulpride is categorized as “one of the most effective drugs currently in use for the treatment of schizophrenia.”

Investigators concluded, “Our results provide evidence that the non-cannabimimetic constituent of marijuana, cannabidiol, exerts clinically relevant antipsychotic effects that are associated with marked tolerability and safety, when compared with current medications. … The results … potentially represent a completely new mechanism in the treatment of schizophrenia.”

A review of CBD’s safety profile in humans, published online in 2011 in the scientific journal Current Drug Safety, concluded that the cannabinoid is non-toxic, safe, and well tolerated in humans, even in high doses.

Separate investigations of CBD have documented the cannabinoid to possess a variety of therapeutic properties, including anti-inflammatory, anti-diabetic, anti-epileptic, anti-cancer, and bone-stimulating properties.

For more information, please contact Paul Armentano, NORML Deputy Director, at: Full text of the study, “Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia,” is available online here:

Article From NORML and republished with permission

About Jay Smoker

I have been smoking marijuana for almost twenty years and I have no plans to stop anytime soon. My life was turned upside down in 2009 after getting arrested and tossed in jail for being in the wrong state with legal medical marijuana. I got fed up, and I now devote all my time to ending this insanity.I am responsible for the technical side of this project, but try to chip in when I can, either with syndicated articles or original content.Follow me on Facebook and Twitter.Feel free to email. any questions or concerns. Peace!
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  • TJGreen

    We have CB1 and CB2 receptors, which occur naturally throughout our bodies. When we smoke ganja, THC binds to the CB1 receptor giving you the high, while CBD binds to the CB2 receptor giving you pain relief. Herbs like marijuana are the greatest medicines the earth has to offer us.

    I call it getting high, but Wikipedia calls it:

    Endocannabinoid-mediated depolarization-induced suppression of inhibition, a very common form of short-term plasticity in which the depolarization of a single neuron induces a reduction in GABA-mediated neurotransmission. Endocannabinoids released from the depolarized post-synaptic neuron bind to CB1 receptors in the pre-synaptic neuron and cause a reduction in GABA release.


     If you want a strain with high CBD check out Harlequin:

  • DarkerMatter

    I heard about this a long time ago, I guess its now scientifically official.Â

    Mr Green (TWB) has so much knowledge about cannabis, I wonder how he handles sincere idiots who spout reefer madness propaganda?  It just irks me to the point I just shut down or change the subject.Â

    • TJGreen

      I don’t feed into it. There are lots of uninformed people who just want to argue. They really don’t care about the position, as long as they have one. I always try to redirect them to other issues they should focus on. In the end, I just want people to treat cannabis rationally. If that were the case, it wouldn’t be such a hot topic of discussion. When was the last time you heard of basil madness?

  • Oklahoma Weed

     First degree murder charges to be filed for drug sales in Oklahoma. Oklahoma first degree murder carries the death penalty.